米索前列醇预防剖宫产术后出血的疗效观察

To observe the curative effect of misoprostol in the prevention of hemorrhage after cesarean section

目的:探讨米索前列醇预防剖宫产术后出血的临床疗效。方法:2013年1月-2014年1月收治剖宫产产妇100例,随机分成观察组和对照组各50例,对照组产妇给予常规处理。观察组产妇待手术结束后给予400μg的米索前列醇塞肛治疗。结果:观察组术中出血量(225.4±52.6)ml,术后出血量(149.5±51.3)ml,产后24小时出血(330.2±61.2)ml,发生产后出血2例,产后出血发生率4.0%;对照组术中出血量(228.4±51.7)ml,术后出血量(190.7±56.8)ml,产后24小时出血(435.6±62.3)ml,发生产后出血9例,产后出血发生率18.0%,观察组发生恶心、呕吐3例。两组术中、术后出血比较差异无统计学意义(P>0.05),产后24小时出血和产后出血发生率比较差异有统计学意义(P<0.05)。结论:米索前列醇可以有效预防剖宫产术后出血,值得临床推广应用。

Objective:To discuss the clinical effect of misoprostol in the prevention of hemorrhage after cesarean section.Methods: Admit 100 cases of puerpera with caesarean section from January 2013 to January 2014.They were randomly divided into the observation group and the control group with 50 cases in each group.The puerpera in the control group were given conventional treatment.The puerpera in the observation group were given 400 μg misoprostol by anus treatment after the end of the operation. Results:In the observation group,the amount of bleeding of intraoperative was 225.4 ± 52.6ml.The amount of bleeding of postoperative was 149.5±51.3ml.The amount of bleeding of postpartum 24 hours was 330.2±61.2ml. 2 cases of postpartum hemorrhage,and the postpartum hemorrhage rate was 4%.In the control group,the amount of bleeding of intraoperative was 228.4± 51.7ml.The amount of bleeding of postoperative was 190.7±56.8ml.The amount of bleeding of postpartum 24 hours was 435.6± 62.3ml.9 cases of postpartum hemorrhage,the postpartum hemorrhage rate was 18%.The observation group occurred nausea,vomiting in 3 cases.The intraoperative,postoperative hemorrhage of two groups were not significantly different(P>0.05).The incidence rate of postpartum 24 hours hemorrhage and postpartum hemorrhage were significantly different(P<0.05).Conclusion:Misoprostol can effectively prevent hemorrhage after cesarean section,so it is worthy of clinical application.