首发儿童精神分裂症患者病前行为特征与事件相关电位的关系

The relationship between event related potentials and the premorbid behavior of the first-episode child schizophrenia

目的:研究儿童精神分裂症首发患者病前行为特征与事件相关电位的关系。方法:采用Achenbach儿童行为量表,回顾性调查儿童精神分裂症首发患者在6~11岁时的行为特征。采用事件相关电位P300对患者的认知功能进行评估。用t检验比较CBCL量表高分组与低分组患者治疗前后P300各数据间的差别。结果:研究组与对照组CBCL量表社会能力总分、行为问题总分、抑郁因子分、社会退缩因子分、攻击性因子分之间差异具有统计学意义(Z=-2.820,-2.325,-2.561,-2.837,-2.759;P<0.05),社会能力总分与治疗前P300潜伏期呈负相关(r=-0.231,P<0.05)。结论:首发儿童精神分裂症患者病前社会能力与认知功能存在相关关系,社会能力较低的患者认知功能损害较严重。

Objective:To study the relationship between event related potentials and the premorbid behavior of the first-episode child schizophrenia.We reviewed the behavior characteristics of the first-episode child schizophrenia when they were 6 to 11 years old,who were detected by Achenbach Child Behavior Checklist.We assessed the cognitive function of patients by the event-related potential P300.We used t test to compare the difference of each P300 data before and after the treatment between the group with the CBCL scale high achievers and low achievers.Results:The difference of social competence scores,the total score of cbcl,the score of depression factor,the score of social withdrawal factor,the score of aggressive factor of the CBCL scale between the study group and the control group were statistically significant(Z=-2.820,-2.325,-2.561,-2.837,-2.759;P<0.05).The total score of social capacity and the P300 latency before the treatment was negatively correlated(r=-0.231,P<0.05).Conclusion:There are some correlation between the social abilities and cognitive function of the first-episode child schizophrenia.The lower of social ability,the more serious damage of cognitive.