摘要
目的:观察吡格列酮联合胰岛素治疗2型糖尿病的临床效果。方法:收治经饮食控制及单用胰岛素治疗效果欠佳的2型糖尿病患者62例,加用吡格列酮治疗4周和12周后,测定空腹血糖(FPG)、餐后2小时血糖(2hPG)及糖化血红蛋白(HbA1c),观察胰岛素用量的变化、低血糖发生率以及不良反应。结果:吡格列酮联合胰岛素治疗后4周及12周后FPG、2hPG和HbAlc较治疗前明显下降(P<0.01),每日胰岛素用量由(75±7)U减至(30±3)U(P<0.01),低血糖发生率显著下降,个别患者出现下肢轻度水肿不良反应。结论:饮食控制及单用胰岛素治疗效果欠佳的2型糖尿病患者加用吡格列酮治疗,可使血糖得到持续改善,并能减少全天胰岛素用量,改善胰岛素抵抗,并且不良反应轻微。
Objective:To explore the curative effect of pioglitazone combined with insulin in the treatment of type 2 diabetes. Methods:62 patients with type 2 diabetes who had poor effect treated with diet control and insulin alone were selected,who added pioglitazone treatment.At the forth week and twelfth week after the start of treatment,we measured fasting blood glucose(FPG),2 hours postprandial blood glucose(2hPG) and glycosylated hemoglobin(HbA1c),and observed the changes of insulin dosage, incidence of hypoglycemia and adverse reaction.Results:At the forth week and twelfth week after the start of treatment with pioglitazone combined with insulin,FPG,2hPG and HbAlc were significantly lower than that before treatment(P<0.01).Daily insulin dosage was reduced from 75±7U to 30±3U(P<0.01).The incidence of hypoglycemia was significantly decreased. Individual patients appeared adverse reaction of mild lower limb edema.Conclusion:For the patients with type 2 diabetes who had poor effect treated with diet control and insulin alone,the application of pioglitazone can get a lasting improvement of blood sugar, reduce the insulin dosage of a whole day and improve insulin resistance.And adverse reactions are mild.
