利培酮对精神分裂症患者糖脂代谢的影响

Effect of risperidone on glucolipid metabolism in schizophrenic patients

目的:探讨利培酮对精神分裂症患者糖脂代谢的影响。方法:2012年1月-2013年12月收治精神分裂症患者80例。所有患者均单一服用利培酮,入院时及治疗1、2个月后查空腹血糖(FBG)、血胆固醇(CHOL)、血甘油三酯(TG)。同时测量患者的体重指数(BMI)和腹围。结果:利培酮治疗2个月后有关神经系统不良反应有20例(25%),其中静坐不能14例,震颤6例。与治疗前比较,利培酮治疗1、2个月后CHOL、TG、BMI有显著性增高(P<0.05),而FBG和腹围改变不明显(P>0.05)。另外,治疗后2个月的CHOL、TG较治疗后1个月水平比较差异有统计学意义(P<0.05)。结论:利培酮能引起精神分裂症患者的糖脂代谢异常,尤其是血脂异常。

Objective:To discuss the effect of risperidone on glucolipid metabolism in schizophrenic.Methods: 80 cases of patients with schizophrenic were admitted from January 2012 to December 2013.All patients were single taking risperidone,check the fasting blood glucose(FBG),serum cholesterol(CHOL),serum triglyceride(TG)on admission and after 1,2 months of treatment.At the same time, measure body mass index(BMI)and abdominal circumference of patients.Results:The nervous system adverse reactions of risperidone after 2 months of treatment was 20 cases(25%),among 14 cases was cathisophobia,6 cases was tremble.Compared with before treatment,the CHOL,TG,BMI of risperidone after 1,2 months of treatment were significantly increased(P<0.05),while FBG and abdominal circumference did not change significantly(P>0.05).In addition,CHOL,TG after 2 months of treatment had statistical significance comparing with that after 1 month of treatment(P<0.05).Conclusion:Risperidone can cause glucolipid metabolic abnormalities in schizophrenic patients,especially the dyslipidemia.