摘要
目的:探讨胰岛素泵治疗1型糖尿病的临床疗效。方法:2013年2月-2014年1月收治1型糖尿病患者100例,随机分为胰岛素泵持续皮下胰岛素输注(CSⅡ)组和传统的多次皮下注射胰岛素法(MSⅡ)组各50例。CSⅡ组给予胰岛素泵持续皮下泵入短效优泌林,据血糖值调整用量。MSⅡ组于三餐前皮下注射短效优泌林和睡前皮下注射中效优泌林。结果:两组患者治疗前空腹血糖、餐后2小时血糖比较差异无统计学意义(P>0.05),治疗后均明显下降,与治疗前比较差异有统计学意义(P<0.05)。CSⅡ组下降幅度明显优于MSⅡ组,两组治疗后比较差异有统计学意义(P<0.05)。CSⅡ组胰岛素用量26.9±8.0U/日,未发生低血糖反应,MSⅡ组胰岛素用量34.6±6.5U/日,发生低血糖反应2例(4.0%),两组比较差异有统计学意义(P<0.05)。结论:胰岛素泵治疗1型糖尿病,具有血糖控制效果好、胰岛素应用量少、发生低血糖率低等优点,值得临床推广。
Objective:To investigate the clinical efficacy of insulin pump in treatment of type 1 diabetes.Methods:100 cases with type 1 diabetes were selected from February 2013 to January 2014.They were randomly divided into the continuous subcutaneous insulin infusion(CS) group and the conventional multiple subcutaneous insulin injection(MS Ⅱ) group with 50 cases in each. Patients in the CS Ⅱ group were given continuous subcutaneous pump into the short acting humulin using insulin pump,adjusted the amount according to blood glucose value.Patients in the MS Ⅱ were given subcutaneous injections of short acting humulin before meals and injected humulin nph before bedtime.Results:The fasting glucose and 2h postprandial blood glucose before treatment in two groups had no statistically difference(P>0.05).Those index decreased after treatment,and there was statistically difference when compared with those index before treatment(P<0.05).The decreased of the CS Ⅱ group was more pronounced than that of the MS Ⅱ group,and the difference was statistically significant between the two groups after treatment(P<0.05). Insulin dosage of the CS Ⅱ was(26.9±8)U/d,and there were no hypoglycemia reaction.Insulin dosage of the MS Ⅱ was(34.6± 6.5)U/d,and 2 cases occured hypoglycemia(4%).The difference was statistically significant between the two groups(P<0.05). Conclusion:Insulin pump used in the treatment of type 1 diabetes,can control blood glucose better, use less insulin,and low rate of hypoglycemia,so it is worthy of clinical promotion.
