叶酸联合维生素C逆转萎缩性胃炎患者癌前病变的疗效

Curative effect of folic acid combined with vitamin C in the treatment of atrophic gastritis patients with precancerous lesions

目的:探讨叶酸联合维生素C逆转萎缩性胃炎患者癌前病变的作用。方法:将127例慢性萎缩性胃炎(CAG)伴肠上皮化生和(或)异型增生患者随机分为试验组63例和对照组64例,试验组在常规幽门螺旋杆菌(Hp)根治基础上给予叶酸联合维生素C,对照组仅给予常规Hp根治。比较两组临床症状缓解率、胃镜和组织病理检查变化、Hp转移率等指标的差异。结果:治疗组在临床症状、胃镜和组织病理学检查等方面的总有效率分别为95.2%、90.5%和87.3%,而对照组分别为73.4%、68.7%和34.4%,两组相比差异有统计学意义(P<0.05)。试验组Hp转阴率96.7%,和对照组(91.5%)相比差异无统计学意义(P>0.05)。结论:在常规Hp根治基础上,联合叶酸和维生素C能够显著缓解萎缩性胃炎患者的临床症状,有效地逆转癌前病变。

Objective:To explore the curative effect of folic acid combined with vitamin C in the treatment of atrophic gastritis patients with precancerous lesions.Methods:127 cases with chronic atrophic gastritis(CAG) complicated with intestinal metaplasia and(or) dysplasia were randomly divided into the experimental group with 63 cases and the control group with 64 cases.The experimental group were treated with folic acid combined with vitamin C on the basis of conventional helicobacter pylori(Hp)eradication,while the control group were treated with routine Hp radical.We evaluated and compared the differences of remission rate of clinical symptoms,gastroscopy and histopathology changes,Hp transfer rate between the two groups.Results:In the treatment group,the total efficiency of clinical symptoms,endoscopic examination and pathology were 95.2%,90.5% and 87.3%respectively.The control group were 73.4%,68.7% and 34.4% respectively.The difference was significant difference(P<0.05).In the experimental group,Hp negative rate was 96.7%,and the control group was 91.5%.There was no significant difference(P>0.05).Conclusion:On the basis of conventional Hp radical,folic acid combined with vitamin C can relieve the clinical symptoms of patients with atrophic gastritis,and effectively reverse precancerous lesions.