瘢痕子宫中期引产用药分析

The analysis of drug use in induction of scar uterine mid pregnancy

目的:探索米非司酮联合依沙吖啶及卡前列甲酯栓终止妊娠中期瘢痕子宫的效果。方法:选择瘢痕子宫再次妊娠20~27周215例,随机分为研究组110例和对照组105例。研究组口服米非司酮25mg,服药150mg后经腹羊膜腔注入依沙吖啶100mg,产后肛塞卡前列甲酯栓;对照组单用依沙吖啶100 mg经腹羊膜腔注入,产后肌注缩宫素。观察两组患者用药至胚胎娩出时间、胎盘娩出时间、产后2小时出血量及产后24小时出血量。结果:两组引产成功率比较差异无统计学意义(P>0.05)。研究组用药至胚胎娩出时间、胎盘娩出时间、产后2小时出血量及产后24小时出血量均优于对照组,差异均有统计学意义(P<0.05)。结论:妊娠中期瘢痕子宫引产在排除用药禁忌证后,采用米非司酮联合依沙吖啶及卡前列甲酯栓进行引产安全有效。

Objective:To investigate the effect of mifepristone combined with ethacridine lactate and carboprost methylate suppositorites in terminating scar uterine mid pregnancy.Methods:215 cases with scar uterine pregnancy 20~27 weeks were selected.They were randomly divided into the study group with 110 cases and the control group with 105 cases.The study group were given oral mifepristone 25 mg,injection of rivanol 100 mg by transabdominal amniocentesis after taking 150 mg medication,anal saika forefront of methyl suppository after delivery.The control group were only given injection of ethacridine 100 mg abdominal amniotic cavity and intramuscular injection of oxytocin after delivery. Observe the time from givening medication to embryo placental delivery,placental delivery time,amount of bleeding at 2 hours and 24 hours after delivery of two groups.Results:There was no statistically difference in the success rate of induced labor of two groups(P>0.05).The time from givening medication to embryo placental delivery,placental delivery time,amount of bleeding at 2 hours and 24 hours after delivery of the study group were better than that of the control group.The difference was statistically significant(P<0.05).Conclusion:Using of mifepristone combined with ethacridine lactate and carboprost methylate suppositorites in mid-term pregnancy uterine scar induced labor was safe and effective,after exclusion of medication contraindications.