摘要
目的:探讨贝那普利联合缬沙坦治疗早期糖尿病肾病的临床疗效及对UAE的影响。方法:2012年4月-2013年4月收治早期糖尿病肾病患者120例,作为研究对象。随机将患者分为A、B、C三组,每组40例。其中A组单独采用贝那普利作为治疗用药;B组单独采用缬沙坦作为治疗用药;C组采取贝那普利联合缬沙坦作为治疗用药,比较三组在治疗前后,组与组之间的差异和在4、8、12周后的UAE变化情况,并采取统计学方式进行处理分析。结果:三组患者在治疗后的UAE值都得到了明显的改善,其中C组的总治疗有效率达到了90%,相比较B组65%和A组75%差异均有统计学意义(P<0.05)。从治疗时间上来分析,第4周开始,三组患者的UAE都持续下降,并在第12周时效果最为明显。从下降趋势上,C组效果要优于A组和B组,且差异具有统计学意义(P<0.05)。结论:采取贝那普利联合缬沙坦治疗早期糖尿病肾病效果显著,值得推广。
Objective:To explore the curative effect and effect on UAE of benazepril combined with valsartan in the treatment of early diabetic nephropathy.Methods:120 cases with early diabetic nephropathy were selected from April 2012 to April 2013.They were as the research objects.They were randomly divided into A,B,C three groups with 40 cases in each.A group were alone treated with benazepril.B group were alone treated with valsartan.C were treated with benazepril combined with valsartan.The differences between the groups before and after treatment were compared.The changes of UAE after 4,8,12 weeks were compared.It took statistical approach for processing analysis.Results:After the treatment,the UAE of the three groups were obviously improved.The total treatment effectiveness of C group reached 90%.There were significant differences compared with 65% of B group and 75% of A group(P<0.05).From the time of treatment to analyze,the UAE of the three groups were continued decline on the begin of the fourth week.The effect of the twelfth week was most obvious.In the decreasing trend,the effect of C group was better than that of A group and B group.The difference was statistically significant(P<0.05).Conclusion:The benazepril combined with valsartan in the treatment of patients with early diabetic nephropathy has a significant effect.It is worthy of promotion.
