奥曲肽联合凝血酶对肝硬化合并上消化道出血的治疗效果分析

Analysis of the therapeutic effect of octreotide combined with thrombin in the treatment of upper gastrointestinal bleeding in patients with cirrhosis

目的:探讨奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的效果。方法:收治肝硬化合并上消化道出血患者60例,随机分组,对照组采用奥曲肽进行治疗,试验组采用奥曲肽联合凝血酶进行治疗,观察两组预后效果。结果:试验组总有效率96.7%,高于对照组76.7%,差异有统计学意义(P<0.05);试验组止血时间(17.2±2.4)小时,相比对照组(28.3±3.3)小时更短,差异有统计学意义(P<0.05);试验组症状改善时间(24.3±4.53)小时,相比对照组(72.6±6.12)小时更短,差异有统计学意义(P<0.05)。结论:采用奥曲肽联合凝血酶治疗肝硬化合并上消化道出血疗效确切,缩短了患者的止血时间和症状改善时间,值得推广和普及。

Objective:To explore the therapeutic effect of octreotide combined with thrombin in the treatment of upper gastrointestinal bleeding in patients with cirrhosis.Methods:60 cases with upper gastrointestinal bleeding and cirrhosis were selected.They were randomly divided into the control group and the experimental group.The control group were treated with octreotide.The experimental group were treated with octreotide combined with thrombin.We observed the prognosis of two groups.Results:The total efficiency of the experimental group(96.7%) was significantly higher than that of the control group(76.7%),and the difference was statistically significant(P<0.05). The hemostatic time of the experimental group[(17.2 ± 2.4) hours ]was significantly shorter than that in the control group [(28.3±3.3) hours],and the difference was statistically significant(P<0.05).The symptom improvement time of the experimental group[(24.3±4.53) hours] was significantly shorter than that of the control group[(72.6 ± 6.12) hours],and the difference was statistically significant(P<0.05).Conclusion:The effect of application of octreotide combined with thrombin in the treatment of upper gastrointestinal bleeding in patients with cirrhosis is significant.It shortens the hemostatic time and symptom improvement time.It is worthy of promotion and popularization.