摘要
目的:评价危重毒物、药物中毒患者经过不同血液净化方式(血液透析或血液灌流)治疗后的临床疗效。方法:2010年1月-2013年12月收治急性中毒患者158例,按照入院顺序分为血液透析组和血液灌流组各79例,血液透析组采用血液透析的血液净化方式,血液灌流组采用血液灌流的血液净化方式,两组患者均给予相同的基础治疗措施:洗胃、利尿、导泻、吸氧、解毒剂及拮抗剂等,对比两组采用不同血液净化方式治疗后的治愈率、死亡率及昏迷时间。结果:血液灌流组治愈74例(93.2%),死亡5例(6.8%),平均昏迷时间(36.7±10.5)小时;血液透析组治愈66例(83.6%),死亡13例(16.4%),平均昏迷时间(73.1±16.2)小时,两组数据对比差异有统计学意义(P<0.05)。结论:临床应用血液灌流的血液净化方式治疗危重中毒患者可有效缩短患者昏迷时间,提高患者治愈率,帮助患者快速恢复,回归社会。
Objective:To explore the clinical curative effect of different ways of blood purification(hemodialysis and hemoperfusion) in the treatment of cases with severe poisoning or drug poisoning.Methods:158 cases with acute poisoning were selected from January 2010 to December 2013.They were divided into the hemodialysis group and hemoperfusion group with 79cases in each group according to the order of admission.The hemodialysis group were treated with hemodialysis,while the hemoperfusion group were treated with hemoperfusion.Two groups were given the same basic treatment measures:gastric lavage,diuretic,purgative,oxygen inhalation,antidote and antagonist and so on.We compared the cure rate,mortality and the duration of coma of the two groups.Results:In the hemoperfusion group,74 cases(93.2%) were cured.5 cases(6.8%) died.The average time of coma was(36.7±10.5)hours.In the hemodialysis group,66 cases(83.6%) were cured.13 cases(16.4%)died.The average time of coma was(73.1 ± 16.2)hours.There were statistically significant differences between the two groups(P<0.05).Conclusion:The application of hemoperfusion in the treatment of cases with severe poisoning,can effectively shorten the time of coma,improve the cure rate of patients,and help patients recover quickly and return to society.
