摘要
目的:探讨手足口病合并病毒性脑炎患儿血清内皮素-1(ET-1)水平和神经元特异性烯醇化酶(NSE)水平的临床意义。方法:采用酶联免疫吸附(ELISA)对20例手足口病合并病毒性脑炎(脑炎组)和20例单纯手足口病患儿(手足口病组)进行了血清ET-1及NSE水平测定,并与20例健康儿(对照组)进行比较。结果:脑炎组血清ET-1和NSE水平(94.12±12.14pg/ml、8.64±2.55μg/L)明显高于对照组(57.39±8.69pg/ml;5.56±1.79μg/L)和单纯手足口病组(62.03±9.40pg/ml、6.00±1.30μg/L),差异有统计学意义(P<0.001)。脑炎组血清ET-1及NSE经治疗后下降为(75.85±9.97)pg/ml、(6.81±1.95)μg/L,差异有统计学意义(P<0.001)。结论:手足口病合并病毒性脑炎时患儿血清ET-1及NSE显著升高,对血清ET-1及NSE的检测有利于早期诊断手足口病合并病毒性脑炎。
Objective:To explore the clinical significance of serum endothelin-1(ET-1) and neuron specific enolase(NSE) levels of hand-food-mouth disease children with viral encephalitis.Methods:The serum endothelin-1 and neuron specific enolase were detected in 20 cases of hand-food-mouth disease children with viral encephalitis and 20 cases of hand-food-mouth disease children by enzyme linked immunosorbent assay(ELISA),and they were compared with 20 cases of normal children.Results:The serum ET-1 and NSE levels of the encephalitis group were(94.12±12.14)pg/ml and(8.64±2.55)μg/L.Those of the control group were(57.39±8.69)pg/ml and(5.56±1.79)μg/L.Those of the simple hand-food-mouth disease group were(62.03±9.40)pg/ml and6±1.30 μg/L.The encephalitis group was significantly higher than the control group and the simple hand-food-mouth disease group.The difference was statistically significant(P<0.001).The serum ET-1 and NSE of the encephalitis group after treatment were decreased to(75.85±9.97)pg/ml and(6.81±1.95)μg/L.The difference was statistically significant(P<0.001).Conclusion:The serum ET-1 and NSE of hand-food-mouth disease children with viral encephalitis are significantly increased.The detection of serum endothelin-1 and neuron specific enolase is conducive to the early diagnosis of viral encephalitis in children with hand-food-mouthdisease.
