口腔鳞癌组织中IGF-1的表达及其临床意义

Expression and clinical significance of IGF-1 in oral aquamous cell carcinoma

目的:探讨胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)组织中的表达,并分析IGF-1的表达水平与口腔鳞癌患者各临床病理特征及其预后的关系。方法:采用免疫组织化学方法检测80例口腔鳞癌患者癌组织及20例正常口腔黏膜组织中IGF-1的表达。结果:①高、中、低分化口腔鳞癌IGF-1表达阳性率分别为44.1%、53.6%和72.2%(P>0.05);IGF-1表达与口腔鳞癌的病理分级呈正相关(rs=0.245)。②IGF-1表达阳性率在Ⅲ~Ⅳ期组、有颈部淋巴结转移组中分别明显高于Ⅰ~Ⅱ期组、无颈部淋巴结转移组(P<0.05)。③IGF-1阴性表达的口腔鳞癌患者3年生存率(71.4%)明显高于阳性者的(29.0%)(P<0.05)。结论:口腔鳞癌组织中IGF-1表达与肿瘤的分期、分化程度、淋巴结转移及预后有关。

Objective:To investigate the expression of insulin-1ike growth factor 1(IGF-1) in oral squamous cell carcinoma(OSCC) tissues and analyze the clinicopathologic features and outcomes of OSCC on basis of IGF-1 expression.Methods:Immunohistochemical technique was used to detect the expression of IGF-1 in OSCC tissues(n=80) and normal tissues(n=20).Results: ① IGF-1 was positively expressed in cases of well differentiated(44.1%),moderately differentiated(53.6%) and poorly differentiated(72.2%)(P>0.05),and it showed positive correlation with pathological grade of OSCC(r=0.245). ② The expression rate of IGF-1 in stage Ⅲ,Ⅳand cases with positive neck lymph node groups was significantly higher than that of Ⅰ,Ⅱand those with negative neck lymph node(P<0.05).③The 3-year survival in OSCC patients with IGF-1 negative was significantly longer as compared with those with positive IGF-1(71.4% vs 29%,P<0.05).Conclusion:IGF-1 expression level in OSCC tissues is associated with tumor stage and differentiation,involvement of lymph node metastasis and prognosis.