不同剂量阿利沙坦酯在轻中度高血压患者中的应用效果观察

Application effect observation of different doses of allisartan isoproxil in patients with mild to moderate hypertension

目的:评价不同剂量的阿利沙坦酯在轻中度高血压病患者中的应用效果。方法:本试验采用的方法为双盲、随机、阳性药物对照设计。2013年1月-2014年8月收治轻中度高血压患者200例,经过2周安慰剂导入,随机平均分为4组。分别为阿利沙坦酯80 mg组50例、160 mg组50例、240 mg组50例(试验组)和替米沙坦50 mg组50例(对照组)。试验组和对照组在试验过程,每次服用药物4片/次,1次/日,口服,共服用8周。结果:在经过口服药物8周之后,4组患者舒张压与收缩压均有显著下降,但阿利沙坦酯片随剂量增加血压下降绝对值增加,但无明确的剂量-效应关系。结论:阿利沙坦酯能够显著降低轻中度高血压患者血压。血压下降绝对值随阿利沙坦酯片剂量增加而增加,但无明显的剂量-效应关系。

Objective:To evaluate the application effect of different doses of allisartan isoproxil in patients with mild to moderate hypertension.Methods:This study adopted double blind,randomized,positive drug control design method.200 cases with mild to moderate hypertension were selected from January 2013 to August 2014.After 2 weeks of placebo,the patients were randomly divided into 4 groups.50 cases were 80 mg allisartan isoproxil group.50 cases were 160 mg group.50 cases were 240 mg group(the experimental group) and 50 cases were 50 mg telmisartan group(the control group).In the experimental process of the two groups,the cases took 4 tablets each time,1 time one day,oral,a total of 8 weeks.Results:After 8 weeks of oral drug,the diastolic blood pressure and systolic blood pressure of patients in the 4 groups were significantly decreased.Through the comparison,the dose of allisartan isoproxil was increased,and the absolute value of blood pressure decline was increased,but there was no clear dose-effect relationship.Conclusion:Allisartan isoproxil can significantly reduce the blood pressure of patients with mild to moderate hypertension.The absolute value of blood pressure decline increases with the increasing doses of allisartan isoproxil,but there is no clear dose-effect relationship.