摘要
目的:探讨在女性难治性精神分裂症患者中应用喹硫平合并无抽搐电休克治疗的临床效果。方法:2011-2013年收治女性难治性精神分裂症患者58例,并遵循随机数字表原则将其分成两组,其中28例实施氯氮平治疗者设为对照组,30例实施喹硫平合并无抽搐电休克治疗者设为观察组,评估两组的临床治疗结局,总结治疗经验。结果:观察组总有效率86.7%,优于对照组的67.9%,比较差异有统计学意义(P<0.05)。观察组治疗第1、2及8周的简明精神病量表(BPRS)评分均比对照组有优越性(P<0.05),而在不良反应发生率方面,两组对比差异无统计学意义(P>0.05)。结论:为女性难治性精神分裂症患者提供喹硫平合并无抽搐电休克疗法进行治疗,能够帮助患者早日控制病情,临床疗效更为理想、可靠,是今后医院提高本病治疗水平的关键。
Objective:To explore the clinical effect of quetiapine combined with non convulsively electroconvulsive therapy in treatment of female refractory schizophrenia.Methods:58 female patients with refractory schizophrenia were selected from 2011 2013.They were randomly divided into the control group with 28 cases and the observation group with 30 cases according to folthe random number table method.We evaluated the clinical therapeutic effects in the two groups,and summarized the experienof treatment.Results:In the observation group,the total effect was 86.7%,and that of the control group was 67.9%.The differenwas statistically significant(P<0.05).In the observation group,the brief psychiatric rating scale(BPRS) score at the first,secoand 8th weeks after treatment were significantly better than those of the control group(P<0.05),while in the symptom recurrenrate,there was no significant difference(P>0.05).Conclusion:The application of quetiapine combined with non convulsiveelectroconvulsive therapy in the treatment of female refractory schizophrenia can as early as possible control the disease.Tclinical efficacy is significant.It is the key to improve the treatment level of this disease in the future.
关键词
喹硫平
无抽搐电休克
女性
精神分裂症
Quetiapine
Non convulsively electroconvulsive therapy
Female
Schizophrenia
