硫酸镁与孟鲁司特联合治疗小儿支气管哮喘的临床疗效观察

Clinical curative effect observation of magnesium sulfate combined with montelukast therapy in the treatment of bronchial asthma

目的:观察小儿支气管哮喘应用硫酸镁与孟鲁司特联合疗法的临床疗效。方法:2011年2月-2014年2月收治支气管哮喘患儿142例,随机平均分为对照组和研究组,每组71例,对照组给予硫酸镁治疗,研究组给予硫酸镁与孟鲁司特联合疗法治疗,记录并分析两组相关情况。结果:研究组干咳、过敏性鼻炎、呼吸困难、心功能衰竭以及面部浮肿常见临床表现改善情况优于对照组,比较差异均具有统计学意义(P<0.05)。头晕、呕吐、便秘和皮疹及腹泻不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:小儿支气管哮喘应用硫酸镁与孟鲁司特联合疗法的临床疗效更显著,值得临床推广。

Objective:To observe the clinical efficacy of application magnesium sulfate combined with montelukast therapy on children bronchial asthma.Methods:142 children with bronchial asthma were selected from February 2011 to February 2014.They were randomly divided into the control group and the study group with 71 cases in each.The control group received the treatment of magnesium sulfate.The study group were given magnesium sulfate combined with montelukast.We recorded and analyzed the relevant circumstances of two groups.Results:The common clinical manifestations of dry cough,allergic rhinitis,difficulty in breathing,heart failure and puffy face of the study group improved better than that of the control group,and the differences were statistically significant(P<0.05).The incidence of dizziness,vomiting,constipation and diarrhea and rash adverse reaction had no significant difference between two groups(P>0.05).Conclusion:Magnesium sulfate combined with montelukast treated on children bronchial asthma can acheive more significant clinical efficacy,so it is worthy of clinical promotion.