摘要
目的:探讨医院药房常见拆零药品维生素B1、对乙酰氨基酚片的稳定性分析与管理方法。方法:将维生素B1、对乙酰氨基酚片在规定环境下进行分装留样,在第0、14、28、56以及84天内对于药品的含量进行测定。结果:维生素B1片在实验第28天之后的测定中,其平均标示量测定结果92.83%,已经达到标准的临界值范围,并且在第56天的测定时,测定结果达到了96.14%,已经显示其不符合标准或者已经发生异常变化;对乙酰氨基酚片含量变化并不明显,在84天后也处于合格范围内。结论:拆零药品应根据各自的药品性质选择相对应的药品包装材料和存放环境,同时注意在分装药品的外包装上注明其有效期。
Objective:To explore the stability analysis and management method of the common dismantle medicines vitamin B1 and acetaminophen tablets in hospital pharmacy.Methods:Vitamin B1 and acetaminophen tablets were separately arranged to take samples in a specified environment.The content of drugs was measured at 0,14,28,56 and 84 days.Results:After 28 days of experiment,the average amount determination result of vitamin B1 was 92.83%,and it had already been reached the standard critical value range.The determination result at 56 days reached 96.14%,and it had shown that the determination result did not meet the standards or had abnormal changes.The content change of acetaminophen tablets was not obvious.It was also in the qualified range after 84 days.Conclusion:Dismantle medicines should be based their pharmaceutical properties to select the corresponding drug packaging materials and storage environment,at the same time, we should pay attention to indicate its validity in the outer packing of repackaged drug.
