米氮平和帕罗西汀在首发抑郁症治疗中的应用效果

Application of mirtazapine and paroxetine in the treatment of first-episode depression

目的:探讨米氮平和帕罗西汀在首发抑郁症治疗中的应用效果。方法:2012年1月-2013年12月收治首发抑郁症患者64例,分为米氮平组和帕罗西汀组,各32例。结果:两组临床疗效差异无统计学意义(P>0.05);治疗后两组汉密尔顿抑郁量表(HAMD)评分均较治疗前差异有统计学意义(P<0.05),两组治疗后HAMD评分差异无统计学意义(P>0.05)。结论:米氮平和帕罗西汀治疗首发抑郁症疗效相当,可有效改善患者抑郁状态,均可作为首选用药。

Objective: To investigate the application effect of mirtazapine and paroxetine in the treatment of first-episode depression.Methods:64 cases with first-episode depressive were selected from January 2012 to December 2013.They were divided into the mirtazapine group and the paroxetine group with 32 cases in each.Results:There was no significant difference in clinical curative effect of the two groups(P>0.05).The Hamilton Depression Scale(HAMD) score of the two groups after treatment significantly improved compared with before the treatment(P<0.05),and there was no difference in HAMD scores of the two groups after treatment.Conclusion:Mirtazapine and paroxetine in the treatment of depression episode have considerable effect,and they can effectively improve patients' depression,so both of them can be used as the first-line therapy.