硝酸甘油不同剂量对急性左心衰竭患者治疗的效果比较及药理作用分析

Treatment and pharmacological effects analysis of different dosage of nitroglycerin in the treatment of patients with acute left heart failure

目的:比较硝酸甘油不同剂量对急性左心衰竭患者治疗的效果,并分析其药理作用。方法:将85例急性左心衰竭患者作为研究对象,均在常规治疗基础上给予静注硝酸甘油。随机分组,A组接受常规剂量硝酸甘油治疗,B组接受大剂量硝酸甘油治疗。对比两组症状缓解时间的差异性。结果:与A组对比,B组症状缓解时间更短,组间差异有统计学意义(P<0.05)。结论:采用硝酸甘油治疗急性左心衰竭疗效确切,其中大剂量硝酸甘油起效迅速,可更快更好地缓解症状,具有积极的临床意义。

Objective:To compare the effect of different doses of nitric acid glycerol in the treatment of patients with acute left heart failure,and to analyze its pharmacological action.Methods:85 patients with acute left heart failure were selected.All of them were given intravenous nitroglycerin on the basis of conventional therapy.They were randomly divided into two groups.The A group received the routine dose of nitroglycerin treatment,and the B group received a large dose of nitroglycerin treatment.We compared the symptomatic relief time of two groups.Results:Compared with the A group,the symptom remission time of the B group was shorter,and the differences between groups were statistically significant(P<0.05).Conclusion:The curative effect of nitroglycerin in the treatment of acute left heart failure is exact,which a large dose of nitroglycerin rapid onset.It can be faster and better relieve symptoms.So it has positive clinical significance.