依帕司他联合α硫辛酸治疗糖尿病周围神经病变临床观察

Clinical observation of epalrestat combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy

目的:观察依帕司他联合α硫辛酸治疗2型糖尿病周围神经病变的临床疗效。方法:将2型糖尿病周围神经病变患者90例随机分为两组。治疗组给予依帕司他联合α硫辛酸治疗,对照组给予α硫辛酸治疗,疗程均为4周;治疗结束后比较两组治疗前后临床疗效及神经传导速度变化。结果:治疗组和对照组治疗总有效率分别为84.4%和62.2%,差异有统计学意义(P<0.05)。两组神经传导速度治疗后有不同程度改善,治疗组的神经传导速度改善情况明显好于对照组。结论:依帕司他联合α硫辛酸治疗2型糖尿病周围神经病变疗效优于α硫辛酸单用,不良反应少。

Objective:To explore the clinical curative effect of epalrestat combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy.Methods:90 cases with type 2 diabetes peripheral neuropathy were randomly divided into two groups.The treatment group were treated with epalrestat combined with alpha lipoic acid,and the control group were treated with alpha lipoic acid.Course of treatment were all 4 weeks.After the end of treatment,we compared the clinical efficacy and the changes of nerve conduction velocity of the two groups.Results:The total efficiency of the treatment group and the control group respectively was 84.4% and 62.2%.The difference was statistically significant(P0.05).After treatment,there were different degrees of improvement of nerve conduction velocity of the two groups.The improvement situation of the treatment group was significantly better than that of the control group.Conclusion:The clinical curative effect of epalrestat combined with alpha lipoic acid in the treatment of 2 type diabetic peripheral neuropathy is berrer than alpha lipoic acid alone,and adverse reaction is small.