抗生素降阶梯治疗小儿重症肺炎的临床疗效

The clinical curative effect of antibiotic de escalation therapy on children with severe pneumonia

目的:探讨抗生素降阶梯治疗小儿重症肺炎的临床疗效。方法:2013年2月-2014年2月收治重症肺炎患儿84例,随机分为观察组和对照组,各42例。观察组采用抗生素降阶梯法治疗,对照组采用常规抗生素治疗,对比两组的治疗效果。结果:观察组治疗后显效28例,有效11例,无效3例,总有效率92.86%;对照组治疗后显效20例,有效10例,无效12例,总有效率71.43%;观察组治疗效果明显优于对照组,差异有统计学意义(P<0.05)。观察组住院时间(21.5±4.4)d,抗生素使用时间(16.7±2.2)d;对照组住院时间(35.1±5.3)d,抗生素使用时间(22.5±3.3)d;观察组在住院时间及抗生素使用时间方面均短于对照组,差异有统计学意义(P<0.05)。结论:采用抗生素降阶梯疗法治疗小儿重症肺炎可以显著缩短治疗时间以及服用抗生素的时间,避免抗生素的滥用,降低不良反应率,提高治疗效果,具有临床推广意义。

Objective:To investigate the clinical curative effect of antibiotic de escalation therapy on children with severe pneumonia.Methods:84 children with severe pneumonia were selected from February 2013 to February 2014.They were randomly divided into the observation group and the control group with 42 cases in each.The observation group were treated with antibiotic de escalation therapy,and the control group were given conventional antibiotic therapy.Compare the curative effect of two groups.Results:In the observation group,28 cases had significant effect after treatment;11 cases were effective;3 cases were ineffective;the total efficiency was 92.86%.In the control group,20 cases were cured after the treatment;10 cases were effective;12 cases were ineffective;the total efficiency was 71.43%.The treatment effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The hospitalization time of the observation group was(21.5±4.4) days;duration of antibiotic use was(16.7±2.2) days;In the control group,hospitalization time was(35.1±5.3) days;duration of antibiotic use was(22.5±3.3) days.The hospitalization times and duration of antibiotic use of the observation group both were shorter than those of the control group,and the differences were statistically significant(P<0.05).Conclusion:The antibiotic de escalation therapy on children with severe pneumonia can significantly shorten treatment time and taking antibiotics time.It also can avoid the abuse of antibiotics,reduce the adverse reaction rate,and improve the therapeutic effect,so it is worthy of clinical promotion.