调强放疗联合紫杉醇与顺铂化疗治疗局部晚期鼻咽癌的临床疗效

Clinical efficacy of intensity modulated radiation therapy combined with paclitaxel and cisplatin chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma

目的:研究分析调强放疗联合紫杉醇与顺铂化疗用于局部晚期鼻咽癌的治疗效果。方法:2009年1月-2012年1月收治局部晚期鼻咽癌患者42例,均采取调强放疗联合紫杉醇与顺铂化疗进行治疗,并观察全部患者的近期疗效、不良反应以及远期生存率、控制率、转移率情况。结果:全部患者均可以顺利完成治疗,近期疗效(即为治疗结束后1个月内):完全缓解7例,部分缓解28例,稳定5例,进展2例,总有效率83.33%。远期疗效:随访2年发现,总生存率88.10%(37/42),鼻咽、颈部2年局部控制率分别是92.86%(39/42)、95.24%(40/42),远处转移率21.43%(9/42)。结论:调强放疗联合紫杉醇与顺铂化疗用于局部晚期鼻咽癌的治疗近期效果可观,显著提高了患者远期生存率,减少了局部复发、远处转移的发生。

Objective:To explore the clinical efficacy of intensity modulated radiation therapy combined with paclitaxel and cisplatin chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma.Methods:42 cases with locally advanced nasopharyngeal carcinoma were selected from January 2009 to January 2012.They were treated with intensity modulated radiation therapy combined with paclitaxel and cisplatin chemotherapy.We observed the curative effect in the near future,all the adverse reactions of patients and the survival rate,metastasis rate,control rate.Results:All patients were successfully completed treatment.The recent curative effect(1 month after the end of the treatment period):7 cases had complete remission;28 cases had partial remission;5 cases were stable;2 cases were progress;the total efficiency was 83.33%.Long term effects:follow-up of 2 years,the total survival rate was 88.10%(37/42);nasopharynx and neck 2 years local control rate was 92.86%(39/42) and 95.24%(40/42);distant metastasis rate was 21.43%(9/42).Conclusion:The recent effect of intensity modulated radiation therapy combined with paclitaxel and cisplatin chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma is significant.It can significantly improve patient survival rate and reduce the local recurrence and distant metastasis.