米非司酮联合米索前列醇终止妊娠的临床效果分析

The analysis of clinical effect of mifepristone combined with misoprostol for pregnancy termination

目的:探讨米非司酮联合米索前列醇终止妊娠的临床效果。方法:2013年2月-2014年5月收治药物终止妊娠孕妇76例,随机分成对照组和观察组,各38例,对照组给予米非司酮150 mg,患者在服药前后2 h均保持空腹,观察组在对照组的基础上于第3天早晨给予米索前列醇600μg口服治疗,如患者在服药6 h后无或轻微腹痛,继续给予600μg,观察患者妊娠囊排出情况,必要时实施清宫手术,并做好生命体征的监护。结果:观察组开始宫缩时间、产后出血和总产程明显低于对照组,差异具有统计学意义(P<0.05)。在观察组中,完全流产35例(92.1%),不全流产3例(7.9%);在对照组中,完全流产15例(39.5%),不全流产18例(47.4%),失败5例,差异具有统计学意义(P<0.05)。结论:米非司酮联合米索前列醇终止妊娠的完全流产率高,值得临床推广。

Objective:To explore the clinical effect of mifepristone combined with misoprostol for pregnancy termination.Methods:76 pregnant woman with medication pregnancy termination were selected from February 2013 to May 2014.They were random Ly divided into the control group and the observation group with 38 cases in each.The control group were given mifepristone 150 mg,who were kept fasting before and after medication 2 hours.On the basis of in the control group,the observation group were given misoprostol 600 μg oral treatment on the third day morning,if the patients had no or slight stomachache 6 hours after taking the drugs,they were continued to give 600 μg.The gestational sac discharge conditions of patients were observed.The operation would implement when necessary,and we would do a good job of vital signs monitoring.Results:The began contractions time,the postpartum hemorrhage and the total production process of the observation group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).In the observation group,35 cases(92.1%) were complete abortion;3cases(7.9%) were incomplete abortion.In the control group,15 cases(39.5%) were complete abortion;18 cases(47.4%) were incomplete abortion;5 cases were failed;the difference was statistically significant(P<0.05).Conclusion:The complete abortion rate of mifepristone combined with misoprostol for pregnancy termination is high.It is worthy of the clinical promotion.