摘要
目的:观察七叶皂苷钠注射液辅助治疗脑出血后继发脑水肿的临床效果。方法:将60例脑出血患者随机分为观察组和对照组,各30例。观察组静注七叶皂苷钠注射液,10 mg/次,1次/12h,连续使用7 d,后改为10 mg/次,1次/d,连续使用5 d,其他脱水药减半。对照组静脉输注甘露醇250 mL,1次/6~8 h,连续使用7 d。所有患者均进行连续的颅内压监护,并于治疗前及治疗后第7~14天观察患者头颅CT及神经功能缺损评分。结果:观察组颅内压下降幅度及CT复查示脑水肿程度和对照组比较差异无统计学意义(P>0.05);观察组的神经功能缺损评分、脑水肿程度及因脱水引起并发症的发生率明显低于对照组(P<0.05)。结论:七叶皂苷钠注射液具有较强的降低颅内压和减轻脑水肿作用,能明显降低因单一使用脱水药引起电解质紊乱及肾功能障碍的发生率。
Objective:To observe the clinical effect of sodium aescinate injection in adjuvant treatment of secondary brain edema after cerebral hemorrhage.Methods:60 patients with cerebral hemorrhage were randomly divided into the observation group and the control group with 30 cases in each.The observation group were given intravenous injection of sodium aescinate injection,10 mg one time,per 12 hours 1 time,continuous use of 7 days,later change to 10 mg one time,1 time one day,continuous use of 5 days,other dehydration medicines were halved.The control group were given intravenous infusion of mannitol 250 mL,per 6~8 hours 1time,continuous use of 7 days.All patients were given continuous monitoring of intracranial pressure.The head CT and neural function defect scale of patients were observed on 7~14 days before treatment and after treatment.Results:The intracranial pressure descend range and cerebral edema degree of CT of patients with cerebral hemorrhage in the observation group were compared with these of the control group,and there was no significant difference(P>0.05).The neurologic impairment score,cerebral edema degree and the incidence rate of complications caused by dehydration of the observation group were significantly lower than those of the control group(P<0.05).Conclusion:Sodium aescinate injection has stronger effect of decreasing intracranial pressure and relieving cerebral edema.It can significantly reduce the incidence rate of electrolyte disorder and renal dysfunction caused by single use of dehydrant.
关键词
七叶皂苷钠注射液
脑出血
脑水肿
Sodium aescinate injection
Cerebral hemorrhage
Cerebral edema
