妊娠合并重型戊型肝炎32例临床分析

Clinical analysis of 32 pregnancy women with severe hepatitis E

目的:探讨妊娠合并重型戊型肝炎临床特点。方法:2004年1月-2010年1月收治妊娠合并重型戊型肝炎患者32例,对其临床资料(实验室检查、诊断、治疗及预后)进行回顾性分析。结果:32例患者中存活率43.75%,死亡率56.25%。26例妊娠晚期产妇中新生儿存活率11.54%,死亡率88.46%(其中死胎率69.23%);6例产褥期产妇中新生儿存活率100%。另外,妊娠合并重型戊型肝炎主要表现为黄疸、肝脏肿大等。结论:妊娠合并重型戊型肝炎预后效果较差,病死率较高,为此需早期准确诊断及积极治疗,以保护母婴安全。

Objective:To investigate the clinical characteristics of pregnancy women with severe hepatitis E.Methods:32pregnancy women with severe hepatitis E were selected from January 2004 to January 2010.We retrospectively analyzed their clinical data(laboratory examination,diagnosis,treatment and prognosis).Results:Among 32 patients,the survival rate was 43.75%;the mortality rate was 56.25%.Neonatal survival rate of 26 late pregnancy maternal was 11.54%;the mortality rate was 88.46%(among which the stillbirth rate was 69.23%).Neonatal survival rate in 6 cases of puerperal women was 100%.In addition,pregnancy complicated with severe hepatitis E was mainly performenced jaundice,liver enlargement.Conclusion:Pregnancy complicated severe hepatitis E always has poor prognosis,and the mortality rate is high,so it is necessary to accurate diagnosis and aggressive treatment early,in order to protect the safety of mother and infant.