摘要
目的:探讨胃癌患者手术治疗前后血清Hcy、Cysc和IL-8水平的变化及临床意义。方法:对30例胃癌患者应用放射免疫分析法、免疫法和胶乳增强免疫比浊法进行了手术治疗前后血清Hcy、Cysc和IL-8水平检测,并与35例健康人作比较。结果:胃癌患者手术前血清Hcy、Cysc和IL-8水平均高于正常人组,其差异有统计学意义(P<0.01);而手术后6个月的检测数据与正常人组比较,其差异无统计学意义(P>0.05);相关性分析结果显示血清Cysc、IL-8水平与Hcy水平呈显著正相关,其差异有统计学意义(P<0.01)。结论:检测胃癌患者血清Hcy、Cysc和IL-8水平的变化可作为诊断和疗效观察的指标。
Objective:To investigate the changes of serum Hcy,Cysc and Il-8 levels before and after operation and its clinical significance in patients with gastric cancer.Methods:Serum Il-8(with RIA),Serum Hcy(with immuno chemistry) and cysc(with latex-enchanced immunoturbidimetry assay) were determined in 30 patients with gastric cancer both before and after operation as well as in 35 controls.Results:Before the operation,the levels of serum Hcy,Cysc and IL-8 in the patients were significantly higher than those in controls(P<0.01).After operation for 6 months,the levels were not significantly different from those in controls(P>0.05).Serum Hcy level were positively correlated with serum Cysc and IL-8 levels(r=0.571 2,0.608 2,P<0.01).Conclusion:Serum levels of Hcy,Cysc and IL-8 may be useful as an indicalor for diagnosis and priedicting therapeutic efficacy after operatim in patients with gastric cancer.
