部分脾栓塞联合抗病毒治疗乙肝肝硬化脾功能亢进临床观察

Clinical observation of partial splenic embolization combined with antivirus treatment in hepatitis B cirrhosis hypersplenism

目的:分析和总结部分脾栓塞联合抗病毒治疗乙肝肝硬化脾功能亢进的效果。方法:利用部分脾栓塞联合阿德福韦酯治疗60例乙肝肝硬化脾功能亢进患者,对肝功能、血常规、血病毒载量、门静脉内径、脾脏厚度以及脾静脉内径等变化情况进行监测,并随访3个月。结果:治疗后,患者的外周血细胞上升、病毒量下降、肝功能得到改善,门静脉压力降低、脾脏缩小,消化道出血减少。结论:对部分脾栓塞联合抗病毒治疗乙肝肝硬化脾功能亢进非常安全,治疗效果也非常好,值得进行临床推广和应用。

Objective:To analyze and summarize the effect of partial splenic embolization combined with antivirus treatment in hepatitis B cirrhosis hypersplenism.Methods:60 patients with hepatitis B cirrhosis hypersplenism were treated with partial splenic embolization combined with adefovir dipivoxil.The changes of liver function,blood routine,blood viral load,partal vein diameter,spleen thickness and diameter of splenic vein were monitored.And they were followed up for 3 months.Results:After this method of treatment,the increased peripheral blood cells,decreased viral load and hepatic function of patients were improved.The portal venous pressure was decreased.The spleen was diminished.The gastrointestinal bleeding was reduced.Conclusion:The partial splenic embolization combined with antivirus treatment in hepatitis B cirrhosis hypersplenism is very safe.The treatment effect is also very good.It is worthy of clinical popularization and application.