盐酸纳洛酮联合脉络宁治疗急性脑梗死40例疗效观察

Clinical observation of 40 cases of naloxone hydrochloride combined with Mailuoning in the treatment of acute cerebral infarction

目的:探讨盐酸纳洛酮联合脉络宁治疗急性脑梗死的临床疗效。方法:2013年3月-2014年3月收治急性脑梗死患者80例,随机分成观察组和对照组各40例,对照组给予血塞通注射液0.4 g+5%葡萄糖注射液250 m L,脉络宁注射液30 m L+5%葡萄糖注射液250 m L,1次/d,连续治疗14 d。观察组在对照组的基础上加用纳洛酮20 mg+0.9%氯化钠注射液250 m L,静滴,1次/d,连用14 d。结果:观察组基本治愈12例,显著进步16例,进步10例,无效2例,总有效率95.0%;对照组基本治愈7例,显著进步17例,进步11例,无效5例,总有效率87.5%,两组比较差异有统计学意义(P<0.05)。观察组NDS评分、ADL和ESS评分明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论:盐酸纳洛酮联合脉络宁治疗急性脑梗死疗效显著,值得推广。

Objective:To explore the clinical effect of naloxone hydrochloride combined with Mailuoning in the treatment of acute cerebral infarction.Methods:80 patients with acute cerebral infarction were selected from March 2013 to March 2014.They were randomly divided into the observation group and the control group with 40 cases in each group.The control group were treated with Xuesaitong injection 0.4 g+5% Glucose Injection 250 m L,Mailuoning injection 30 m L+5% Glucose Injection 250 m L,1 time/d,continuous treatment of 14 d.The observation group were treated with naloxone 20 mg+250 m LNS on the basis of the control group,intravenous drip,1 time/d,for 14 d.Results:In the observation group,12 cases were basically cured;16 cases had significant progress;10 cases had progress;2 cases were invalid;the total effective rate was 95%.In the control group,7 cases were basically cured;17 cases had significant progress;11 cases had progress;5 cases were ineffective;the total efficiency was 87.5%;the difference was statistically significant(P<0.05).In the observation group,NDS score,ADL score and ESS score were significantly better than the control group,and the difference was statistically significant(P<0.05).Conclusion:The clinical effect of naloxone hydrochloride combined with Mailuoning in the treatment of acute cerebral infarction is significant.It is worthy of promotion.