摘要
目的:探讨依达拉奉治疗急性脑出血患者的临床疗效。方法:2013年2月-2014年4月收治急性脑出血患者126例,随机分成对照组和观察组,各63例,对照组按照降颅压、止血、抗感染和维持水电解质平衡治疗原则,给予醒脑静注射液20 m L+5%葡萄糖注射液250 m L,静滴,糖尿病患者用0.9%氯化钠注射液静滴;观察组在对照组的基础上给予依达拉奉注射液30 mg+0.9%氯化钠注射液静滴。两组均连续治疗21 d。结果:观察组基本痊愈19例,显著进步29例,进步12例,无效2例,死亡1例,总有效率95.2%;对照组基本痊愈15例,显著进步23例,进步11例,无效13例,死亡1例,总有效率77.8%,两组比较差异有统计学意义(P<0.05)。观察组治疗前NIHSS评分(11.2±1.8)分,治疗后(3.4±0.6)分,对照组治疗前NIHSS评分(11.2±1.7)分,治疗后(5.3±0.9)分,两组治疗前后比较差异有统计学意义(P<0.05),两组治疗后比较差异有统计学意义(P<0.05)。结论:依达拉奉治疗急性脑出血患者疗效显著,值得推广。
Objective:To explore the clinical effect of edaravone in the treatment of patients with acute cerebral hemorrhage.Methods:126 patients with acute cerebral hemorrhage were selected from February 2013 to April 2014.They were randomly divided into the control group and the observation group with 63 cases in each group.The control group were given reducing intracranial pressure,hemostasis,anti infection and maintaining water and electrolyte balance treatment,and Xing Nao Jing injection 20 m L+5% glucose injection 250 m L for intravenous drip.Diabetic patients were treated by 0.9%NS intravenous drip.The observation group were given edaravone injection 30 mg+0.9%NS by intravenous drip on the basis of the control group.Two groups were treated for 21 days.Results:In the observation group,19 cases were basically cured;29 cases were significant progress;12 cases were progress;2 cases were invalid;1 case was died;the total efficiency was 95.2%.In the control group,15 cases were basically cured;23 cases were significant progress;11 cases were progress;13 cases were invalid;1 case was died;the total efficiency was 77.8%.The difference was statistically significant(P<0.05).In the observation group,before treatment NIHSS score was(11.2+1.8) points;after treatment the score was(3.4+0.6) points.In the control group,before treatment NIHSS score was(11.2+1.7) points;after treatment score was(5.3 + 0.9) points.Compared the two groups before and after treatment,the difference was statistically significant(P<0.05);compared the two groups after treatment,the difference was statistically significant(P<0.05).Conclusion:The clinical effect of edaravone in treatment of patients with acute cerebral hemorrhage is significant.It is worthy of popularization.
