胰腺癌患者血清CA19-9、CEA、TGF-α和TGF-β1水平检测的临床意义

Clinical significance of detecting serum CA19-9,CEA,TGF-α and TGF-β1 in patients with pancreatic cancer

目的:探讨胰腺癌患者血清CA19-9、CEA、TGF-α和TGF-β1水平的变化及临床意义。方法:对30例胰腺癌患者应用放射免疫分析法进行血清CA19-9、CEA、TGF-α和TGF-β1水平检测,并与35例正常人比较。结果:胰腺癌患者血清CA19-9、CEA、TGF-α和TGF-β1水平均非常显著高于正常人组(P<0.01)。且血清CA19-9水平与CEA、TGF-α、TGF-β1水平呈正相关(r=0.492 5、0.601 5、0.598 4,P<0.01)。结论:对胰腺癌患者进行血清CA19-9、CEA、TGF-α和TGF-β1水平的检测并分析其变化情况,对疾病的诊断和治疗均有一定的临床价值。

Objective:To investigate the changes of serum CA19-9 CEA,TGF-α and TGF-β 1 in patients with pancreatic cancer and its clinical significanc.Methods:30 patients with pancreatic cancer were detected the level of serum CA19-9,CEA,TGF-α and TGF-β1 by radioimmunoassay,and they were compared with the levels of 35 normal people.Results:The levels of serum CA19-9,CEA, TGF-α and TGF-β1 in patient with pancreatic cancer were significantly higher than that of the normal group(P<0.01).And there were positively relationship between the level of serum CA19-9 and the levels of CEA,TGF-α,TGF-β1(r=0.4925,0.6015,0.5984,P<0.01).Conclusion:If we detected the levels of serum CA19-9,CEA,TGF-α and TGF-β1in patients with pancreatic cancer and analyzed the changes of those levels,it can bring some certainly clinical values on the diagnosis and treatment of this diseases.