门冬氨酸钾镁治疗蒽环类化疗药物所致心脏毒性的疗效观察

Observation of the curative effect of Potassium Aspartate magnesium in treatment of anthracycline induced cardiotoxicity

目的:探讨患者预防性使用门冬氨酸钾镁改善蒽环类化疗药物对心脏的毒性评价。方法:本组肿瘤患者82例,治疗组42例在应用蒽环类药物同时使用门冬氨酸钾镁20 m L+5%葡萄糖溶液500 m L静滴,对照组40例单用化疗药物。比较两组心电图改变及LVEF改变。结果:两组在心电图改变差异有统计学意义(P<0.05),两组LVEF改变差异有统计学意义(P<0.05)。结论:预防性使用门冬氨酸钾镁对蒽环类药物的心脏毒性有一定的保护作用。

Objective:To investigate the evaluation of prophylactic use of Potassium Aspartate magnesium improving anthracycline cardiac toxicity of patients.Methods:82 patients with tumor were selected.The treatment group with 42 cases were treated with anthracene ring drugs at the same time used potassium aspartate magnesium 20 m L+5% GS 500 m L intravenous drip,and the control group with 40 cases were only with chemotherapy drugs.Results:The two groups had very significant differences in the ECG change(P<0.05);the LVEF change of two groups had significant difference(P<0.05).Conclusion:The prophylactic use of Potassium Aspartate magnesium drugs on the cardiac toxicity of anthracene ring has protective effect.