摘要
目的:探讨莫沙必利联合铝碳酸镁治疗胆汁反流性胃炎(RBG)的临床效果。方法:2009年1月-2014年5月收治胆汁反流性胃炎患者118例,随机分为观察组与对照组,观察组应用莫沙必利联合氢氧化铝进行治疗,对照组采用莫沙必利联合复方阿嗪米特进行治疗,总疗程4周,比较两组患者临床效果、症状改善及不良反应发生情况。结果:观察组总有效率89.8%,对照组总有效率74.6%,观察组明显优于对照组(P<0.05);两组治疗前后腹痛、腹胀、恶心、呕吐症状评分比较具有统计学意义(P<0.05),治疗后观察组各症状评分显著低于对照组(P<0.05);两组患者用药不良反应比较差异无统计学意义(P>0.05)。结论:莫沙必利联合铝碳酸镁来治疗胆汁反流性胃炎可有效减少胆酸的反流,是一种合理安全的治疗方案。
Objective:To investigate the therapeutic effect of mosapride combined with hydrotalcid in the treatment of bile reflux gastritis(RBG).Methods:118 patients with bile reflux gastritis were selected from January 2009 to May 2014.They were randomly divided into the observation group and the control group.The observation group applicated mosapride combined with aluminum hydroxide,while the control group treated with mosapride combined compound azintamide.The total treatment course was 4 weeks.Then we compared the occurrence of clinical effect,symptom improvement and side reaction between two groups.Results:The total effective rate of the observation group was 89.8%,while the control group was 74.6%,and the observation group was significantly better than the control group(P<0.05);the differences were statistically significant in abdominal pain, abdominal distention,nausea,vomiting symptoms score before and after the treatment in two groups(P<0.05),after the treatment,each symptom score of the observation group was significantly lower than that of the control group(P<0.05);there was no significant differences in adverse reactions after treatment between two groups(P>0.05).Conclusion:Mosapride combined with hydrotalcite in the treatment of bile reflux gastritis can effectively reduce the reflux of cholic acid,and combination of counter flow of gastric acid,so this treatment is reasonable and safety.
