血液灌流(HP)抢救急性重度药物及毒物中毒的临床分析

Clinical analysis of hemoperfusion(HP) for rescue of acute severe drug and poison intoxication

目的:通过观察分析血液灌流(HP)抢救急性重度药物及毒物中毒的临床效果,评估其临床应用价值。方法:2013年1月-2014年1月收治急性重度药物及毒物中毒患者40例,根据治疗方式的不同随机均分为观察组和对照组,各20例,对照组采用药物机械和洗胃导泻等常规方式进行治疗,观察组在常规治疗的基础上采用血液灌流方式进行治疗。观察并对比两组患者的治疗效果,主要观察指标为两组患者平均昏迷时间、平均住院时间和治疗总有效率。结果:观察组的平均昏迷时间和平均住院时间均少于对照组。观察组存活18例,死亡2例,治疗总有效率90.00%;对照组存活15例,死亡5例,治疗总有效率75.00%,观察组治疗效果明显优于对照组,差异有统计学意义(P<0.05)。结论:血液灌流术联合常规治疗方式抢救治疗急性重度药物及毒物中毒患者具有较高的治疗效率和治疗效果,有效缩短了患者的昏迷时间与住院治疗时间,临床治疗总有效率较高,保障了患者的生存质量,具有临床推广应用的价值。

Objective:Through the observation of hemoperfusion(HP) treatment effect of acute severe drug and poison intoxication,to evaluate its clinical value.Methods:40 patients with acute severe drug and poison intoxication were selected from January 2013 to January 2014.According to the different treatments,they were randomly divided into the observation group and the control group with 20 cases in each group.The control group was treated with pharmaceutical machinery and gastric lavage and catharsis and other conventional way,and the observation group was treated with hemoperfusion on the basis of the conventional treatment.We observed and compared the efficacy of the two groups.The main observation indexes were the average time of coma,the average hospitalization time and the total efficiency of treatment of the two groups.Results:In the observation group,the average time of coma and the average hospitalization time were shorter than those of the control group.In the observation group,18 cases were survived;2 cases died;the total efficiency was 90%.In the control group,15 cases were survived;5 cases died;the total efficiency was 75%.In the observation group,the therapeutic effect was significantly better than the control group,and the difference was statistically significant(P<0.05).Conclusion:Hemoperfusion combined with conventional therapy had high therapeutic efficiency and treatment effect in the rescue treatment of acute severe drug and poison intoxication patients.It can effectively shorten the coma patients with time and the time of hospitalization.The total effective rate is higher.It can guarantee the life quality of the patients,and it has clinical application value.