奥美拉唑联合法莫替丁治疗慢性胃炎50例效果分析

Effect analysis of omeprazole combined famotidine in the treatment of 50 cases with chronic gastritis

目的:探讨奥美拉唑联合法莫替丁治疗慢性胃炎的临床效果。方法:2014年1-9月收治慢性胃炎患者100例,随机分成观察组和对照组各50例。对照组于饭前口服奥美拉唑20 mg/次,2次/d,连续治疗15 d,观察组在对照组的基础上于睡前加服法莫替丁20 mg/次,1次/d,连续治疗15 d。结果:经过治疗后观察组显效43例(86.0%),有效5例(10.0%),无效2例,总有效率96.0%。对照组显效32例(64.0%),有效6例(12.0%),无效12例,总有效率76.0%,两组比较差异有统计学意义(P<0.05)。观察组随访1个月,幽门螺杆菌阴转37例(77.1%)。随访2个月,幽门螺杆菌阴转46例(95.8%)。随访3个月,幽门螺杆菌阴转47例(97.9%)。对照组随访1个月,幽门螺杆菌阴转18例(37.5%)。随访2个月幽门螺杆菌阴转28例(58.3%)。随访3个月幽门螺杆菌阴转30例(62.5%)。两组比较差异有统计学意义(P<0.05)。结论:奥美拉唑联合法莫替丁治疗慢性胃炎疗效显著,值得推广。

Objective:To explore the effect of omeprazole combined famotidine in the treatment of 50 cases with chronic gastritis. Methods:100 cases of patients with chronic gastritis from January to September in 2014 were randomly divided into the observation group and the control group,with 50 cases in each group.The control group took omeprazole 20 mg/times anteprandial oral,2 times/d,with continuous treatment for 15 d,and the observation group took famotidine 20 mg/times,1 time/d on the basis of the control group,with continuous treatment for 15 d.Results:After the treatment,43 cases were markedly improved(86.0%);5 cases were effective(10.0%);2 had no effect in the observation group and the total effective rate was 96.0%.32 cases were markedly improved(64.0%);6 cases were effective(12.0%);12 had no effect in the control group and the total effective rate was 76.0%.There was statistically significant difference between the two groups(P<0.05).37 cases of the observation group had helicobacter pylori negative conversion followed up for 1 month(77.1%).46 cases of the observation group had helicobacter pylori negative conversion followed up for 2 months(95.8%).47 cases of the observation group had helicobacter pylori negative conversion followed up for 3 months(97.9%).18 cases of the control group had helicobacter pylori negative conversion followed up for 1 month(37.5%).28 cases of the control group had helicobacter pylori negative conversion followed up for 2 months(58.3%).30 cases of the control group had helicobacter pylori negative conversion followed up for 3 months(62.5%).There was statistically significant difference between the two groups (P<0.05).Conclusion:Omeprazole combined famotidine in the treatment of chronic gastritis had good effect,which was worth promoting.