老年慢性心衰患者抗心衰治疗后血浆脑利钠肽水平分布及影响因素分析

Analysis of plasma brain natriuretic peptide level distribution and influence factors after anti-heart failure treatment in elderly patients with chronic heart failure

目的:分析老年慢性心衰患者抗心衰治疗后血浆脑利钠肽(BNP)水平分布及影响因素。方法:2012年1月-2013年6月收治老年慢性心衰患者93例,对临床资料进行回顾性分析,按出院时BNP水平分为正常组与观察组,进行因素分析。结果:观察组冠状A病变率、入院心率水平、收缩压、舒张压、肺淤血率、左室射血分数、肺动脉高压高于正常组,抗心律失常药物应用率低于正常组,差异具有统计学意义(P<0.05)。低收缩压、肺淤血成为出院后BNP超正常标准独立危险因素。结论:应用抗心衰治疗后,收缩压仍显著下降,合并肺瘀血的患者,出院时BNP水平较高。

Objective:To analyze the plasma brain natriuretic peptide level distribution and influence factors after anti-heart failure treatment in elderly patients with chronic heart failure.Methods:The clinical data of 93 cases of elderly patients with chronic heart failure from January 2012 to June 2013 were analyzed retrospectively,and they were divided into the observation group and the normal group according to the BNP levels on discharge from the hospital.We analyzed the factors.Results:The coronary lesions rate,the level of heart rate as admission,systolic pressure,diastolic pressure,the pulmonary bleeding rate,left ventricular ejection fraction,pulmonary hypertension in the observation group were all higher than those of in the normal group;the utility rate of antiarrhythmic drugs was lower than that in the normal group;the difference was statistically significant(P<0.05). Lower systolic pressure and lung congestion became independent risk factors of super standard BNP after discharge.Conclusion:The systolic pressure declines significantly after anti-heart failure treatment,and the BNP level of the patients with lung congestion is higher on discharge from the hospital.