抗生素联合糖皮质激素治疗老年慢性阻塞性肺气肿疗效分析

Curative effect analysis of antibiotics combined with glucocorticoids in the treatment of elderly patients with chronic obstructive pulmonary emphysema

目的:探讨抗生素联合糖皮质激素治疗老年慢性阻塞性肺气肿的作用及临床效果。方法:2011-2013年收治慢性阻塞性肺气肿老年患者84例,随机分为试验组与对照组,各42例。对照组给予抗生素、平喘、解痉、化痰、持续性低流量给氧、常规卧床休息等对症支持性治疗。试验组在对照组的基础之上联合糖皮质激素进行治疗,比较两组患者的治疗效果和不良反应等情况。结果:试验组总有效率88.09%,对照组总有效率69.04%,差异具有统计学意义(P<0.05)。不良反应发生情况:对照组胸痛2例,恶心2例;试验组呕吐1例,腹泻1例,两组之间差异具有统计学意义(P<0.05)。结论:抗生素联合糖皮质激素治疗老年慢性阻塞性肺气肿疗效显著,使用方便,不良反应较少,因而值得在临床上进行推广。

Objective:To investigate the function and clinical effect of antibiotics combined with glucocorticoid in the treatment of elderly chronic obstructive pulmonary.Methods: 84 elderly patients with chronic obstructive pulmonary emphysema were selected from 2011 to 2013.They were randomly divided into the experimental group and the control group with 42 cases in each.The control group were treated with antibiotics,antispasmodic,phlegm,asthma,persistent low flow oxygen to support treatment,routine bed rest symptomatic.The experimental group on the basis of the control group combined with glucocorticoid treatment.We compared the curative effect and adverse reaction of the two groups.Results:The total effectiveness of the experimental group was88.09%.The total effectiveness of the comparison group was 69.04%,with significant difference(P<0.05).The incidence of adverse reaction:in the control group,2 cases of chest pain,2 cases of nausea;in the experience group,1 cases of vomiting,diarrhea in 1 cases,the differences between the two groups with statistically significant(P<0.05).Conclusion:The effect of antibiotics combined with corticosteroid in the treatment of elderly patients with chronic obstructive pulmonary emphysema is significant,convenient,less adverse reactions,so it is worth to be popularized in clinic.