摘要
目的:探讨小剂量叶酸干预治疗对老年H型高血压患者血浆同型半胱氨酸(Homocysteine,Hcy)水平及臂踝脉搏波传导速度(ba PWV)的影响。方法:2013年1月-2014年3月收治老年H型高血压患者180例,随机分为试验组(96例)和对照组(84例),入选年龄均≥60岁,试验组和对照组均强调生活方式的改变和正规药物降压等常规治疗,试验组在常规治疗的基础上同时给予口服小剂量叶酸0.8 mg/d。随访6个月,比较两组患者血浆Hcy水平及ba PWV的变化情况。结果:与治疗前及对照组相比,试验组小剂量叶酸治疗6个月后血浆Hcy水平下降显著(P<0.05),且ba PWV速度有明显减慢(P<0.05),而对照组血浆Hcy水平及ba PWV速度未见明显变化。结论:叶酸干预治疗可以明显降低老年H型高血压患者血浆Hcy水平,且患者ba PWV也有明显改善。
Objective:To investigate the effect of small dose of folic acid to blood homocysteine(Homocysteine,Hcy) level and brachial ankle pulse wave velocity(ba PWV) in 180 elderly patients with type H hypertensive.Methods:180 elderly patients with type H hypertensive were selected from March 2013 to January 2014.They were randomly divided into the experimental group(96cases) and the control group(84 cases).The selected age were over 60 years old.The experimental group and the control group were emphasized lifestyle changes and regular antihypertensive drug and other conventional treatment.The experimental group were given oral low dose folic acid 0.8 mg/d on the basis of routine treatment.Follow up of 6 months,we compared the plasma Hcy levels and brachial ankle pulse wave velocity(ba PWV) changes of two groups.Results:Compared with that before the treatment and the control group,after 6 months of the small dose of folic acid treatment,the plasma Hcy level of the test group decreased significantly(P<0.05),and the ba PWV rate has slowed down significantly(P<0.05),while the levels of plasma Hcy and ba PWV speed of the control group had no obvious change.Conclusion:Folic acid intervention treatment can obviously reduce the plasma Hcy levels in patients with elderly patients with type H hypertension,and ba PWV were improved obviously.
出处
《中国社区医师》
2015年第2期29-30,共2页
Chinese Community Doctors
