莫沙必利治疗功能性消化不良的疗效和安全性分析

Analysis of the efficacy and safety of mosapride in the treatment of functional dyspepsia

目的:探讨莫沙必利治疗功能性消化不良的疗效和安全性。方法:2011年10月-2012年8月收治功能性消化不良患者110例,按照随机数字表法将其分为观察组和对照组,各55例,对照组给予多潘立酮治疗,观察组给予莫沙必利治疗,比较两组患者临床疗效、胃排空障碍者餐后4 h残留率及不良反应的发生情况。结果:观察组总有效率(98.2%)明显高于对照组(81.8%),组间比较差异有统计学意义(χ2=6.452,P<0.05),治疗前两组胃排空障碍者餐后4 h残留率差异无统计学意义(χ2=0.462,P>0.05);治疗后观察组明显优于对照组,组间比较差异具有统计学意义(t=5.612,P<0.05);观察组不良反应发生率(9.1%)与对照组(12.7%)比较差异无统计学意义(χ2=0.486,P>0.05)。结论:莫沙必利治疗功能性消化不良疗效确切,有助于改善患者临床症状,且安全性较高,具有很好的临床应用价值。

Objective:To investigate the safety and efficacy of mosapride in the treatment of functional dyspepsia.Methods:110patients with functional dyspepsia were selected from October 2011 to August 2012.They were randomly divided into the observation group and the control group with 55 cases in each.The control group were given domperidone treatment,and the observation group were treated with mosapride.We compared the clinical curative effect,the 4 h residue rate after the meal of the patients with delayed gastric emptying and the incidence of adverse events of the two groups patients.Results:The total effective rate of the observation group(98.2%) was significantly higher than that of the control group(81.8%),and the difference between the groups had statistically significant(χ2=6.452,P<0.05).Before treatment,the postprandial 4 h residual rate of the patients with delayed gastric emptying of the two groups had no significant difference(χ2=0.462,P>0.05);after the treatment,the observation group was significantly better than the control group,the differences between groups had statistically significant(t=5.612,P<0.05).The incidence of adverse reactions of the observation group(9.1%) and the control group(12.7%) had no significant difference(χ2=0.486,P>0.05).Conclusion:The effect of mosapride in the treatment of functional dyspepsia is exactly.It can help to improve the clinical symptoms of patients,and its safety is high,so it has the very good clinical application value.