华法林对老年非瓣膜房颤抗栓疗效及安全性分析

Analysis of the antithrombotic curative effect and safety of warfarin on elderly nonvalvular atrial fibrillation

目的:探讨华法林对老年非瓣膜房颤抗栓疗效及安全性。方法:2011年1月-2013年12月收治老年非瓣膜房颤患者80例,分为华法林组与阿司匹林组,对两组患者的抗栓疗效与安全性进行对比与分析。结果:华法林组患者的终点事件发生率5%,阿司匹林组30%,差异具有统计学意义(P<0.05)。华法林组的出血发生率5%,阿司匹林组5%,差异不具有统计学意义(P>0.05)。结论:华法林在老年非瓣膜房颤治疗中应用抗栓效果良好,具有很高的安全性,且终点事件发生率较低,值得推广与应用。

Objective:To explore the antithrombotic curative effect and safety of warfarin on elderly nonvalvular atrial fibrillation. Methods:80 elderly patients with nonvalvular atrial fibrillation were selected from January 2011 to December 2013.They were divided into the warfarin group and the aspirin group.The antithrombotic curative effect and safety of two groups were compared and analyzed.Results:The endpoint events occurrence rate of patients in the warfarin group was 5%,and that of the aspirin group was 30%;the difference was statistically significant(P<0.05).The bleeding occurrence rate of patients in the warfarin group was 5%,and that of the aspirin group was 5%;the difference was not statistically significant(P>0.05).Conclusion:The application of warfarin in the treatment of elderly nonvalvular atrial fibrillation has good antithrombotic effect,very high security,and lower endpoint events occurrence rate.It is worthy of promotion and application.