地佐辛复合布托啡诺用于剖宫产术后静脉镇痛效果研究

Study on the effect of dezocine combined with bhutto butorphanol in the postoperative intravenous analgesic after cesarean section

目的:观察不同剂量的地佐辛复合布托啡诺用于剖宫产术后静脉镇痛的效果。方法:收治择期剖宫产孕妇90例,随机分为3组(D1、D2、D3),均用布托啡诺0.1 mg/kg加0.9%氯化钠注射液配成60 m L。D1组加地佐辛10mg,D2组加地佐辛5 mg,D3组不加地佐辛。3组均用盐酸布比卡因7.5 mg,容量3 m L,L2~3~L3~4腰椎穿刺单次腰麻下完成手术。胎儿娩出后静注地佐辛5 mg预冲负荷剂量,术毕接镇痛泵。观察产妇镇静、镇痛及并发症的情况。结果:镇痛VAS评分D1、D2组均低于D3组,差异有统计学意义(P<0.05);镇静Ramsay评分D1、D2组均高于D3组,差异有统计学意义(P<0.05)。并发症恶心、呕吐、头痛未见相加作用。结论:地佐辛复合布托啡诺镇痛、镇静比单用布托啡诺效果好,最佳剂量为10 mg。

Objective:To explore the effect of different doses of dezocine combined with bhutto butorphanol in the postoperative intravenous analgesic after cesarean section.Methods:90 cases of elective cesarean section pregnant women were selected.They were randomly divided into three groups(D1,D2,D3).Three groups were treated with bhutto butorphanol 0.1 mg/kg,added with0.9% sodium hydroxide solution for 60 m L.D1 group added dezocine 10 mg.D2 group added dezocine 5 mg,D3 group did not add dezocine.Three groups of pregnant women were treated with bupivacaine hydrochloride 7.5 mg,capacity 3 m L,and they were given surgical treatment with L2~3to L3~4lumbar puncture for single spinal anesthesia.After delivery of fetus,pregnant women were given intravenous dezocine 5 mg for precharge loading dose,after operation,they were given the analgesia pump.We observed the sedation,analgesia and complications.Results:The VAS score of D1 and D2 group was lower than that of D3 group,and the difference was statistically significant(P<0.05).The Ramsay score of D1 and D2 group was higher than that of D3 group,and the difference was statistically significant(P<0.05).In complications,nausea,vomiting,headache had no additive effect.Conclusion:The analgesic and sedation effect of dezocine combined with butorphanol was better than single use of bhutto butorphanol,and optimal dose group was 10 mg.