大剂量雾化重组人干扰素α1b对轮状病毒肠炎患儿的疗效观察

The curative effect observation of large dose of atomization of recombinant human interferon a1b in children with rotavirus enteritis

目的:探讨大剂量雾化人干扰素α1b对治疗轮状病毒肠炎患儿的疗效。方法:收治轮状病毒肠炎患儿146例,按治疗方式分成对照组70例和治疗组76例。对照组实行常规治疗,治疗组在实行常规的治疗上,加用雾化吸入重组人干扰素α1b。吸入的剂量根据患儿的年龄和病情的轻重酌情而定,1次/d,连续治疗3 d;比较两组患者的治疗效果和止泻时间、退热时间。结果:治疗组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗组的止泻时间和退热时间均短于对照组,差异有统计学意义(P<0.05)。结论:大剂量雾化重组人干扰素α1b对治疗小儿轮状病毒肠炎的临床疗效有显著的提高。

Objective:To explore the curative effect of large dose of atomization of recombinant human interferonα1b in children with rotavirus enteritis.Methods:146 children with rotavirus enteritis were selected.According to the treatment,they were divided into the treatment group of 76 cases and the control group of 70 cases.The control group were given conventional treatment,while the treatment group were given atomization of recombinant human interferonα1b on the basis of conventional therapy.Inhalation dose was appropriate depending on the patients’ age and the severity of illness,1 time/day,continuous treatment of 3 days.We compared the effect of treatment and the antidiarrheal time,cooling time of the two groups.Results:In the treatment group,the total efficiency was higher than that of the control group,and the difference had statistical significance(P<0.05).In the treatment group,antidiarrheal time and the cooling time were shorter than the control group,and the difference had statistical significance(P<0.05).Conclusion:The curative effect of large dose of atomization of recombinant human interferon α 1b in children with rotavirus enteritis was significant.