妊娠期糖代谢异常与尿酸、C肽、超敏C反应蛋白、糖化血红蛋白相关性

Correlation of gestational abnormal glucose metabolism and uric acid,C peptide,high sensitivity C reactive protein,glycated hemoglobin

目的:探讨C肽、超敏C反应蛋白、糖化血红蛋白、尿酸及血脂等多因素与妊娠期糖代谢异常的相关性。方法:2010年1月-2011年8月收集分娩孕妇,统计其在孕24~28周前后检测的血糖与尿酸、CRP、血脂、超敏CRP、C肽、糖化血红蛋白、体重、血压及文化背景等,其中异常23例;随机抽取40例正常者为对照。C肽采用电化学发光方法,超敏C反应蛋白采用芬兰试剂,糖化血红蛋白用TDM100糖化血红蛋白分析仪测定。采用多因素分析评价其相关性。结果:多因素联合分析比单个独立因素评价糖代谢异常相关性高。结论:多项联合检测能提前预测糖代谢异常的发生,提前采取治疗措施,预防疾病发生,得到很好的预后效果。

Objective:To explore the correlation of gestational abnormal glucose metabolism and C peptide,high sensitivity C reactive protein,glycated hemoglobin,uric acid,blood lipid and other factors.Methods:Childbirth pregnant womens were selected from January 2010 to August 2011.The blood glucose and uric acid,CRP,blood lipid,high sensitivity CRP,C peptide,glycated hemoglobin that were detected before and after pregnancy 24 to 28 weeks.Weight,blood pressure and cultural background were statistically analyzed,in which 23 cases were abnormal.A random sample of 40 normal persons was as the control.C peptide used electrochemiluminescence method,the high sensitive C reactive protein used finland reagent,the glycated hemoglobin was detected by TDM100 glycated hemoglobin analyzer instrument.The correlation was analyzed and evaluated by multi factors.Results:The multi factor combined analysis in the evaluation of abnormal glucose metabolism correlation was higher than a single independent factor.Conclusion:The multiple combined detection can predict abnormal glucose metabolism in advance.It can advance to take treatment,prevent disease,and obtain very good prognosis effect.