非那雄胺对减少良性前列腺增生患者经尿道电切综合征效果及其作用机制

Study on the effect of finasteride and its mechanism of action on decreasing in patients with benign prostatic hyperplasia transurethral resection syndrome

目的:探讨术前服用非那雄胺是否可减少良性前列腺增生患者出现经尿道电切综合征(TURS)的概率。方法:2013年1月1日-12月31日收治良性前列腺增生患者160例,均采用经尿道前列腺电切手术(TURP)治疗。将其按照随机数字表的方式分成研究组和对照组,各80例。研究组在术前使其服用非那雄胺;对照组在术前不服用非那雄胺。对比各组患者在手术过程中出血量多少,同时比较其血中钠离子的情况。结果:研究组的出血量少于对照组,而血中钠离子的含量则是研究组大于对照组,差异具有统计学意义(P<0.05)。结论:对于良性前列腺患者采用TURP手术治疗时,在其术前服用非那雄胺可以比较有效地降低其出现电切综合征的概率。

Objective:To explore whether preoperative use of finasteride can reduce the probability of transurethral resection syndrome(TURS) emergence in patients with benign prostatic hyperplasia.Methods:160 patients with benign prostatic hyperplasia were selected from January 1 to December 31 of 2013.All of them were treated with transurethral resection of the prostate operation(TURP) for the treatment of operation.According to the random number table method they were randomly divided into the study group and the control group with 80 cases in each group.Patients in the study group use taken finasteride before surgery;while the control group without finasteride before surgery.Then we compared blood volume during the operation in two groups,and compared the sodium ion in its blood situation.Results:The amount of hemorrhage in the study group less than that in the control group,while the content of blood sodium ions in study group was higher than the control group,with significant differences(P<0.05).Conclusion:For the patients with benign prostate transurethral resection of TURP treatment,the probability of transurethral resection syndrome can effectively reduced if taking finasteride before the sugery.