二丁酰环磷腺苷钙联合硝酸异山梨酯治疗稳定型心绞痛的临床疗效观察

Clinical curative effect observation of calcium dibutyryladenosine cyclophosphate combined with isosorbide dinitrate in the treatment of stable angina pectoris

目的:探讨二丁酰环磷腺苷钙联合硝酸异山梨酯治疗稳定型心绞痛的临床疗效。方法:2012年11月-2014年11月收治稳定型心绞痛患者100例,按随机数字表法分为常规组和观察组,各50例。两组患者均给予皮下注射低分子肝素钙、口服阿司匹林、钙拮抗剂或β受体阻滞剂等对症治疗。常规组在对症治疗基础上仅给予硝酸异山梨酯常规治疗,观察组在对症治疗基础上给予二丁酰环磷腺苷钙联合硝酸异山梨酯综合治疗。记录并比较两组患者临床疗效、心电图疗效及不良反应发生率的差异。结果:观察组临床疗效总有效率(90.0%)明显优于常规组(76.0%),差异具有统计学意义(P<0.05);观察组心电图疗效总有效率(92.0%)明显优于常规组(80.0%),差异具有统计学意义(P<0.05);观察组不良反应发生率(8.0%)明显优于常规组(22.0%),差异具有统计学意义(P<0.05)。结论:二丁酰环磷腺苷钙联合硝酸异山梨酯治疗稳定型心绞痛的疗效显著,不良反应发生率低,值得临床推广应用。

Objective:To explore the clinical curative effect of calcium dibutyryladenosine cyclophosphate combined with isosorbide dinitrate in the treatment of stable angina pectoris.Methods:100 patients with stable angina pectoris were selected from November 2012 to November 2014.They were randomly divided into the routine group and the observation group with 50 cases in each according to random number table method.The patients in two groups were given subcutaneous injection of low molecular heparin calcium, oral aspirin,calcium antagonists and beta blockers and other symptomatic treatment.The routine group was given isosorbide dinitrate routine treatment on the basis of symptomatic treatment.The observation group was given calcium dibutyryladenosine cyclophosphate combined with isosorbide dinitrate comprehensive treatment on the basis of symptomatic treatment.The differences between clinical curative effects,electrocardiogram curative effects and adverse reaction occurrence rates of patients in two groups were recorded and compared.Results:The curative effect total effective rate(90.0%) of the observation group was obviously better than 76% of the routine group,and the difference was statistically significant(P<0.05).The electrocardiogram curative effect total effective rate(92.0%) of the observation group was obviously better than 80.0% of the routine group,and the difference was statistically significant(P<0.05).The adverse reaction occurrence rate(90.0%) of the observation group was obviously better than 22.0% of the routine group,and the difference was statistically significant(P<0.05).Conclusion:The calcium dibutyryladenosine cyclophosphate combined with isosorbide dinitrate in the treatment of stable angina pectoris have significant curative effect,and the adverse reaction occurrence rate is low.It is worthy of clinical popularization and application.