新生儿感染性肺炎病原菌85例临床分析

Clinical analysis of 85 cases of pneumonia pathogen infection in neonates

目的:了解新生儿感染性肺炎患者病原菌及药敏实验结果,为临床治疗提供依据。方法:2010年1月-2013年6月收治新生儿感染性肺炎患儿,对其痰培养和药敏进行分析。结果:新生儿感染性肺炎的患儿中送检373例痰标本,其中痰培养阳性85例,阳性率22.8%。常见病原菌依次是大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌等。85株药物敏感试验结果:革兰阴性杆菌对β-内酰胺加酶抑制剂(哌拉西林他唑巴坦、阿莫西林舒巴坦、头孢哌酮舒巴坦)及氨基糖苷类药物较敏感。金黄色葡萄球菌对苯唑西林较敏感。无万古霉素耐药株。结论:所培养检出的致病菌中,以革兰阴性杆菌占主导地位,主要为大肠埃希菌和肺炎克雷伯菌。革兰阳性球菌主要是金黄色葡萄球菌及凝固酶阴性葡萄球菌。药敏结果显示,大肠埃希菌、肺炎克雷伯菌等杆菌对β-内酰胺加酶抑制剂、丁胺卡那敏感;葡萄球菌对苯唑西林较敏感。

Objective:To understand the pathogenic bacteria and drug sensitivity test results of neonatal infection pneumonia patients,and to provide the basis for clinical therapy.Methods:Neonatal infection pneumonia patients were selected from January 2010 to June 2013.Sputum culture and sensitivity results were analyzed.Results:In the neonatal infection in children with pneumonia,373 cases of sputum specimens were submitted,among them,85 cases of sputum culture were positive,and the positive rate was 22.8%.Common pathogens were escherichia coli,klebsiella pneumoniae,staphylococcus aureus and so on.85 strains of drug sensitive test results:gram negative bacilli was sensitive to beta lactam enzyme inhibitor(piperacillin tazobactam,amoxicillin sulbactam and cefoperazone sulbactam) and aminoglycosides.Staphylococcus aureus was sensitive to oxacillin.There was no vancomycin resistant strains.Conclusion:In the culture of pathogenic bacteria detection,G- bacillus was the dominant,they were mainly escherichia coli and klebsiella pneumoniae.G+ cocci mainly staphylococcus aureus and coagulase negative staphylococcus. The drug sensitivity results showed,escherichia coli,klebsiella pneumonia were sensitive to beta lactam enzyme inhibitors and amikacin;staphylococcus was sensitive to oxacillin.