氯胺酮联合丙泊酚在小儿麻醉中的疗效分析

Analysis of the therapeutic effect of ketamine combined with propofol in pediatric anesthesia

目的:分析氯胺酮联合丙泊酚在小儿麻醉中的临床效果,为临床工作者提供参考。方法:2014年1月-2014年10月收治进行手术治疗的患儿100例,将其按随机数字表法分为观察组和对照组,采用氯胺酮联合丙泊酚对观察组(n=50)施行麻醉,采用氯胺酮对对照组(n=50)施行麻醉。记录分析两组患儿围术期的各项生命体征和麻醉苏醒时间。结果:所有患儿均顺利完成手术,观察组麻醉显效36例,麻醉有效14例,麻醉显效率72.00%;对照组麻醉显效27例,麻醉有效23例,麻醉显效率54.00%。两组患儿术后的心率、平均动脉压、血氧饱和度和呼吸频率差异无统计学意义(P>0.05)。手术进行5 min时,两组患儿的平均动脉压差异具有统计学意义(P<0.05)。观察组和对照组的停药后麻醉苏醒时间(18.87±4.57)min和(38.24±10.23)min,观察组的7例患儿和对照组的15例患儿出现呕吐症状,两组患者的麻醉苏醒时间和呕吐情况差异均有统计学意义(P<0.05)。结论:氯胺酮联合丙泊酚的麻醉效果佳,患儿的生命体征平稳,同时可减少氯胺酮的用量,缩短麻醉苏醒时间和减少呕吐躁动情况,具有临床应用价值。

Objective:To analyze the clinical effect of ketamine combined with propofol in pediatric anesthesia,in order to provide the reference for clinical workers.Methods:100 children with surgical treatment were selected from January 2014 to October 2014.They were randomly divided into the observation group and the control group with 50 cases in each.Patients in the observation group underwent anesthesia using ketamine combined with propofol,while patients in the control group only using ketamine.We compared perioperative vital signs and anesthetic recovery time of children in two groups.Results:All the children were completed the operation successfully,in the observation group there were 36 cases with excellent anesthesia effect,14 cases were effective,so the anesthesia excellent rate was 72%;in the control group,there were 27 cases with excellent anesthesia effect,23 cases were effective,the anesthesia excellent rate was 54%.The differences in heart rate,mean arterial pressure,oxygen saturation and respiratory frequency of children had no statistically significant between two groups(P>0.05).At 5min of the operation,the difference in mean arterial pressure was statistically significant between the two groups(P<0.05).The anesthesia recovery time in the observation group and the control group were(18.87 ± 4.57)min and(38.24 ± 10.23)min respectively after discontinuation.There were 7 cases of the observation group and 15 cases of the control group with vomiting,and the differences in anesthesia recovery time and vomiting rate both were significant between the two groups(P<0.05).Conclusion:Ketamine combined with propofol in children anesthesia has good effect,and the childreb can keep stable vital signs.This anesthesia method also can reduce the dosage of ketamine,shorten the anesthesia recovery time,and reduce the vomiting and restlessness,so it is worthy of application in clinical.