呼吸内科患者抗生素相关性腹泻50例临床分析

Clinical analysis of 50 cases of patients with antibiotic associated diarrhea in respiratory medicine

目的:分析呼吸内科患者抗生素相关性腹泻(ADD)。方法:2008年6月-2013年6月收治抗生素相关性腹泻患者50例,回顾性分析临床资料。结果:抗生素在常规剂量的时候,相关性腹泻的发生及严重程度与抗生素种类无关,在给药途径、预防用抗生素差异也没有其显著性。轻症患者用药3~4 d后,病情明显改善,用药1周后症状消失。重症患者用药时间较长,可达2~3周,2例患者(均为脓血便)因原发病死亡。结论:呼吸内科住院患者很容易出现抗生素相关性腹泻,应该根据患者病理生理特征、药敏实验、抗生素药理学特点等来合理选择抗生素,减少联合用药及侵袭性操作,及时补充益生菌以稳定肠道菌群。

Objective:To analyze the patients with antibiotic associated diarrhea in respiratory medicine.Methods:The clinical data of 50 cases of patients with antibiotic associated diarrhea from June 2008 to June 2013 were analyzed retrospectively.Results:As the antibiotic was in the normal dose,the occurrence and severity of antibiotic-associated diarrhea had nothing to do with the antibiotics types,there were no significant differences of administration route,prevention of antibiotics.The symptoms of the patients mild improved after the treatment of 3 to 4 days and the symptoms disappeared after 1 week.Patients with severe needed drug use for a long time and could reach 2 to 3 weeks,and 2 patients (all purulent blood) died of the primary disease.Conclusion:The hospitalized patients were prone to ADD in respiratory medicine and should be given reasonable antibiotics based on the pathologic physiology characteristic of patients,medicine sensitive experiment,the pharmacological characteristics antibiotic,the combination and invasive operation should be reduced and probiotic were supplemented for the stability of intestinal flora.