戊乙奎醚联合机械通气治疗助状素中毒的临床观察

Clinical observation of penehyclidine hydrochloride combined with mechanical ventilation in the treatment of patients with mepiquat poisoning

目的:主要观察戊乙奎醚联合机械通气治疗助状素中毒的疗效。方法:2008年1月1日-2014年12月31日收治口服助状素患者12例,均有瞳孔缩小、流涎、皮肤湿润等中毒表现,其中呼吸心跳骤停1例,呼吸骤停3例,呼吸衰竭8例,除洗胃、护肝、护胃等治疗外,给予戊乙奎醚肌注及气管插管、呼吸机辅助呼吸治疗。结果:全部12例患者均抢救成活,随访无后遗症发生。结论:戊乙奎醚联合机械通气抢救助状素中毒缓解症状明显,疗效确切,值得临床推广使用。

Objective:To observe the curative effect of penehyclidine hydrochloride combined with mechanical ventilation in the treatment of patients with mepiquat poisoning.Methods:12 patients with mepiquat poisoning were selected from January 2008 to December 31,2014.All patients had miosis,salivation,skin moist and other toxic manifestations,1 cases of respiratory and cardiac arrest,3 cases with respiratory arrest,respiratory failure in 8 cases.In addition to gastric lavage,protecting liver,protecting stomach and other treatment,they were given penehyclidine intramuscular injection,endotracheal intubation and assisted ventilation treatment.Results:All 12 patients were rescued survived,follow-up without sequelae.Conclusion:Penehyclidine hydrochloride combined with mechanical ventilation in the treatment of patients with mepiquat poisoning relieve symptoms obviously and efficacy which is worthy of clinical use.