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利拉鲁肽在2型糖尿病合并并发症中的应用(附1例报告) 被引量:1

Application of liraglutide in type 2 diabetes combined with complications(attached 1 case)
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摘要 目的:本文分析利拉鲁肽在1例2型糖尿病患者中的治疗效果。利拉鲁肽对于2型糖尿病患者,不仅可以显著降低血糖、体重、血脂水平,对糖尿病的早期肾病及心血管并发症均起到预防和保护作用,且应用越早受益越大。 In this paper,the author analyzes the treatment effect of liraglutide in 1 patient with type 2 diabetes.Liraglutide for the patient with type 2 diabetes not only can reduce the blood glucose,body weight,blood lipid level,but also can play a preventive and protective effect on the early kidney disease and cardiovascular complications of diabetes.The application is earlier,the benefit is greater.
出处 《中国社区医师》 2015年第16期114-115,共2页 Chinese Community Doctors
关键词 利拉鲁肽 2型糖尿病 并发症 Liraglutide Type 2 diabetes Complications
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  • 1Gaspari T,Welungoda I,Widdop RE,et al.The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis,plaque stability and endothelial function in an ApoE mouse model. Diab Vasc Dis Res . 2013
  • 2M. Marre,J. Shaw,M. Br?ndle,W. M. W. Bebakar,N. A. Kamaruddin,J. Strand,M. Zdravkovic,T. D. Le Thi,S. Colagiuri.Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabetic Medicine . 2009
  • 3Liu Hongbin,Dear Anthony E,Knudsen Lotte B,Simpson Richard W.A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules. The Journal of Endocrinology . 2009
  • 4Zhou SJ,Bai L,Lv,et al.Liraglutide ameliorates renal injury in streptozotocin induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor kb pathway. Mol Med Rep . 2014
  • 5Sun F,Wu S,Wang J,et al.Risk of cardiovascular disease:The effects of diabetes and anti-diabetic drugs-A nested case-control study. Clinical Therapeutics . 2015

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