不稳定性心绞痛伴抑郁症患者采用抗抑郁治疗的价值探讨

Discussion of the value of using antidepressant treatment in unstable angina pectoris patients with depression

目的:观察抗抑郁治疗对不稳定性心绞痛伴抑郁症患者的临床效果。方法:收治不稳定性心绞痛伴抑郁症患者68例,随机分为对照组和试验组,每组34例。对照组给予常规的心血管药物治疗,试验组在对照组的基础上增加奥氮平抗抑郁药物,对两组患者的心绞痛发作情况、硝酸甘油使用剂量及住院次数进行比较。结果:对照组每周发生心绞痛≥1次11例(32.4%)明显少于试验组的28例(85.3%)(P<0.05);对照组每周硝酸甘油用量控制在≤2 mg10例(29.4%)明显少于试验组的27例(79.4%)(P<0.05);动态心电图检测中,试验组疗效明显较好。结论:对不稳定性心绞痛伴抑郁症患者的临床治疗中采用抗抑郁治疗有明显的治疗效果,能较好地提高患者的生存质量。

Objective:To observe the clinical effect of antidepressant treatment in unstable angina pectoris patients with depression.Methods:68 unstable angina pectoris patients with depression were selected.They were randomly divided into the control group and the experimental group with 34 cases in each.The control group was given conventional cardiovascular drug treatment.The experimental group was given mirtazapine antidepressant drug on the basis of the control group.The anginal frequencies,nitroglycerin dosages and hospitalization frequencies of patients in two groups were compared.Results:11cases(32.4%) of weekly angina within 1 time in the control group was less than 28 cases(85.3%) of the experimental group(P<0.05).10 cases(29.4%) of weekly nitroglycerin dosage control within 2 mg in the control group was less than 27 cases(79.4%) of the experimental group(P<0.05).In the dynamic electrocardiogram detection,the curative effect of the experimental group was significantly better.Conclusion:Using antidepressant treatment in the clinical treatment of unstable angina pectoris patients with depression has obvious treatment effect.It better improves the life quality of patients.