细胞色素P450氧化还原酶缺陷和先天性肾上腺皮质增生症

Cytochrome P450 oxidoreductase defects and congenital adrenal hyperplasia

先天性肾上腺皮质增生症可影响肾上腺激素生成,造成促肾上腺皮质激素(ACTH)分泌,刺激肾上腺皮质增生肥大。细胞色素P450氧化还原酶(POR)参与类固醇激素的合成,对先天性肾上腺皮质增生症具有重要影响。

Congenital adrenal hyperplasia can affect the adrenal hormone production,resulting in adrenocorticotropic hormone(ACTH)secretion and stimulate the adrenal hypertrophy.Cytochrome P450 oxidoreductase(POR)involved in the synthesis of steroid hormones have important implications for congenital adrenal hyperplasia.